Ideally, you should harvest your mushrooms 5 days after they start growing. That way you will minimize the mess made if your mushrooms have spored.
If you have experienced a “spore storm” you will know it can make quite a mess. If the air is still, most of it will fall directly under the mushrooms. If you have it placed on a kitchen or bathroom bench, it is usually easy to clean up with a damp cloth. However, the spore is so fine the small air currents in the room will disperse it. So, if you have been away for a few days the spore may have covered a wide area, appearing as fine dust and making it a real chore to clean up.
An ounce of prevention is worth a pound of cure.
Grow the mushrooms in an area that’s easy to clean up. A kitchen or bathroom bench is ideal. Also, keep it away from drafts. (Both of these tips also help with maintaining humidity.)
If you are going away for a few days, put it in the shower cubicle. If it spores, just run the shower.
Is it dangerous? The spore load from a single home-sized “grow kit” should not cause any harm. However, it may cause distress to someone who suffers from allergies or asthma. If you suffer any of these please take extra precautions.
It is worth noting that the air we breathe also contains many fine particles, including bacteria, dust, pollen, and fungal spores. These are not usually an issue for most people. As commercial growers, we wear PPE like respirators etc.
Concerned about the spores or mushroom allergies? here is a link with more information: Unmasking Mushroom Allergy: Symptoms, Diagnosis, and Treatment
Will mushrooms grow in my house? No. Other types of fungi can grow in your house like molds etc, but not these types of mushrooms. Fungi generally will only grow on a host (plant or animal) that they have evolved to co-exist with. The culinary mushrooms (like oyster and Shiitake) grow on decaying hardwood trees, so not likely to grow within your house (for instance on a wooden window sill or floorboards, etc).
Microscopic image of Oyster Mushroom Spore