Cordyceps: Their Potential For Kidney Health – 4 Science Backed Benefits

Cordyceps, are increasingly being studied for their potential benefits to kidney health. While commonly associated with improved energy and immunity, Cordyceps also shows promise in protecting kidneys and aiding people with kidney diseases like chronic kidney disease (CKD).

How Cordyceps May Help the Kidneys

The kidneys maintain fluid, filter waste, and support blood pressure. If they become damaged, toxins build up and health declines. Several types of Cordyceps, especially Cordyceps sinensis and Cordyceps militaris, appear to help protect and improve kidney function through several mechanisms:

1. Lowering Waste Markers: Clinical studies have shown that Cordyceps can reduce blood levels of creatinine and blood urea nitrogen (BUN)—key markers doctors use to track kidney function. In people with CKD, Cordyceps supplementation was linked to significant drops in protein in urine, BUN, and creatinine after three months, suggesting improved kidney filtration[1][4][5].
2. Reducing Proteinuria: Excess protein in urine (proteinuria) is a sign of kidney strain. Research indicates Cordyceps may help decrease proteinuria, reducing stress on the kidneys and slowing disease progression[4][5].
3. Anti-Inflammatory and Antioxidant Effects: Cordyceps contains compounds that help calm inflammation and combat oxidative stress, both of which can worsen kidney damage. Inflammation is a key factor in kidney disease, so herbs that fight it may be especially helpful[2][3].
4. Protection Against Drug and Disease Damage: Some studies suggest Cordyceps helps protect kidneys from damage caused by toxic medications, diabetes complications, and even organ transplant rejection. Animal studies also indicate that Cordyceps can decrease scarring (fibrosis) in the kidneys, which is a common pathway to kidney failure[2][3][6].

Mechanisms Behind the Benefits

Cordyceps appears to work on several biological pathways important for kidney health, such as:

• Blocking inflammatory responses in kidney cells.
• Enhancing the body’s natural antioxidant systems.
• Influencing key molecular pathways like TGF-β/Smad and NF-κB, which control inflammation and tissue repair[2][3].

Human Studies: What Do We Know?

A review of 22 studies involving over 1,700 people with kidney disease found Cordyceps, when used alongside standard treatments, helped reduce harmful waste markers and protein in the urine, and improved kidney function on lab tests[4][5]. Some studies also report improvements in kidney-related anemia and blood protein levels. However, researchers caution that much of this evidence comes from studies with design limitations or small sample sizes, so the results, while encouraging, should be interpreted carefully.

Safety and Use

Cordyceps is generally considered safe in moderate amounts. Side effects are rare but can include mild digestive upset. Since Cordyceps has potential to interact with medications and affect the immune system, people with kidney disease or transplant patients should consult their healthcare provider before use[6].

Conclusion

Emerging research suggests Cordyceps could be a valuable ally for kidney health. It may help lower waste levels, protect against inflammation, slow kidney damage, and offer additional support alongside conventional treatments. While more high-quality studies are needed, current results offer hope—especially for those seeking natural support for their kidneys.

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References:

1. PMC: Cordyceps militaris and CKD biomarkers[1]
2. Frontiers in Pharmacology: Effects on inflammation and fibrosis[2][3]
3. PubMed/Cochrane Reviews: Meta-analysis of Cordyceps for CKD[4][5]
4. WebMD: Kidney protection from drugs and diseases[6]

Sources
[1] Cordyceps militaris Improves Chronic Kidney Disease by Affecting … https://pmc.ncbi.nlm.nih.gov/articles/PMC6462325/
[2] Use of bailing capsules (cordyceps sinensis) in the treatment of … https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1342831/full
[3] Potential Therapeutic Strategies for Renal Fibrosis: Cordyceps and … https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.932172/full
[4] Cordyceps sinensis (a traditional Chinese medicine) for treating … https://pubmed.ncbi.nlm.nih.gov/25519252/
[5] Cordyceps sinensis (a Chinese medicinal herb) for treating chronic … https://www.cochrane.org/evidence/CD008353_cordyceps-sinensis-chinese-medicinal-herb-treating-chronic-kidney-disease
[6] Cordyceps: Benefits and Dangers – WebMD https://www.webmd.com/vitamins-and-supplements/cordyceps
[7] Efficacy of Cordyceps sinensis as an adjunctive treatment in kidney … https://www.sciencedirect.com/science/article/abs/pii/S0965229916304058
[8] Cordyceps sinensis extract protects against acute kidney injury by … https://www.aging-us.com/article/205676/text
[9] 6 Benefits of Cordyceps, All Backed by Science – Healthline https://www.healthline.com/nutrition/cordyceps-benefits
[10] Pharmacological Mechanism and Clinical Research Progress of https://journals.lww.com/imna/fulltext/2025/03000/pharmacological_mechanism_and_clinical_research.1.aspx